Convergence and divergence in the genetics of psychiatric disorders from pathways to developmental stages

S Shohat, A Amelan, S Shifman - Biological psychiatry, 2021 - Elsevier
… risk factors for major neuropsychiatric disorders (schizophreniafunctional convergence
most relevant to a specific condition will likely be shared across different types of genetic variants

Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia

M Kim, JR Haney, P Zhang, LM Hernandez… - Nature …, 2021 - nature.com
genetic variation within the C4 locus 9 . In humans, C4 is encoded by two genes—C4A and
C4B—which exist in different … this network-based, brain-specific functional annotation for C4A …

Convergence and divergence of rare genetic disorders on brain phenotypes: a review

A Raznahan, H Won, DC Glahn… - JAMA psychiatry, 2022 - jamanetwork.com
… and effect sizes of genetic variation on autism spectrum … phenotypic convergence and
divergence between differentgenes in CNVs associated with ASD and schizophrenia with …

[HTML][HTML] Convergent and divergent genes expression profiles associated with brain-wide functional connectome dysfunction in deficit and non-deficit schizophrenia

C Zhou, X Tang, M Yu, H Zhang, X Zhang, J Gao… - Translational …, 2024 - nature.com
… In terms of functional imaging studies, genetic variants of GRIN2A were associated with …
different altered patterns of FC networks in BWAS. Furthermore, convergent and divergent genes

Convergent impact of schizophrenia risk genes

KG Townsley, A Li, PJM Deans, JF Fullard, A Yu… - bioRxiv, 2022 - biorxiv.org
… most frequently arises from common genetic variation that confers … functional similarity of
target genes impacts the degree of convergence, suggesting that risk variants sum in different

New gene discoveries highlight functional convergence in autism and related neurodevelopmental disorders

M Moyses-Oliveira, R Yadav, S Erdin… - … Opinion in Genetics & …, 2020 - Elsevier
… points of convergence among these genes with diverse biological … fold enrichment for rare
inherited variants). This study reported 102 … associated with ASD, NDD, schizophrenia (SCZ), …

[HTML][HTML] Ultra-rare and common genetic variant analysis converge to implicate negative selection and neuronal processes in the aetiology of schizophrenia

WA Akingbuwa, AR Hammerschlag, M Bartels… - Molecular …, 2022 - nature.com
… expressed in different brain cell types and neurons, as well … the functional analyses across
common and rare variants, the … ultra-)rare variant gene-set and cell type enrichment analyses …

[HTML][HTML] Leveraging interindividual variability of regulatory activity for refining genetic regulation of gene expression in schizophrenia

M Alver, N Lykoskoufis, A Ramisch… - Molecular …, 2022 - nature.com
… among genetic variants, coordinated regulatory activity and gene expression. To … gene [20],
and on the convergence of deviations detected in different molecular layers as seen for gene

Identification and prioritization of gene sets associated with schizophrenia risk by co-expression network analysis in human brain

E Radulescu, AE Jaffe, RE Straub, Q Chen… - Molecular …, 2020 - nature.com
different signaling pathways in our co-expression networks … have stressed genes in tier
1 because of the convergence of … some overlap in gene networks between genetic risk and …

Mega-analysis of odds ratio: a convergent method for a deep understanding of the genetic evidence in schizophrenia

P Jia, X Chen, W Xie, KS Kendler… - Schizophrenia …, 2019 - academic.oup.com
… the different types of data and provide a convergent view of … enriched in critical functional
gene sets involved in neuronal … So far, there have been hundreds of inherited genetic variants